Self-employment (SECA) tax is Social Security and Medicare tax for people who work for themselves. When you're an employee, you pay 7.65% for these and your employer pays a matching 7.65%. When you're self-employed, you're both — so you pay the full 15.3%, which catches many first-time freelancers by surprise.
It applies to 92.35% of your net business profit (revenue minus expenses), not to gross revenue. The Social Security portion of 12.4% applies up to an annual wage base; the Medicare portion of 2.9% has no cap. This is entirely separate from federal income tax, which you also owe on the same profit.